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    Evaluation of the pro-oxidant and antioxidant actions of L-DOPA and dopamine in vitro: implications for Parkinson's disease.

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    Authors
    Spencer, J P
    Jenner, A
    Butler, John
    Aruoma, O I
    Dexter, D T
    Jenner, P
    Halliwell, B
    Affiliation
    Neurodegenerative Diseases Research Centre, University of London King's College, UK.
    Issue Date
    1996-02
    
    Metadata
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    Abstract
    The antioxidant and pro-oxidant properties of L-DOPA and dopamine were investigated in vitro. Both compounds inhibited the peroxidation of ox-brain phospholipids, with IC50 values of 8.5 microM for dopamine and 450 microM for L-DOPA. Dopamine and L-DOPA reacted with trichloromethyl peroxyl radicals (CCl3O2.) with rate constants of 2.1 x 10(7)M-1s-1 and 1.3 x 10(7)M-1s-1 respectively. The effects of dopamine and L-DOPA on iron ion-dependent hydroxyl radical generation from H2O2 were complex. In general, low concentrations stimulated OH. formation in the presence of ferric-EDTA and, in the case of L-DOPA, ferric-ADP and ferric citrate chelates. Both compounds also reacted with superoxide radical and hypochlorous acid. The products of the reaction with HOCl could still inhibit alpha 1-antiproteinase and appear to be 'long lived' chloramine-type oxidizing species. Our results suggest that L-DOPA and dopamine might have a complex mixture of pro- and anti- oxidant effects, which could contribute to tissue damage due to oxidative stress in Parkinson's disease and other neurological disorders.
    Citation
    Evaluation of the pro-oxidant and antioxidant actions of L-DOPA and dopamine in vitro: implications for Parkinson's disease. 1996, 24 (2):95-105 Free Radic. Res.
    Journal
    Free Radical Research
    URI
    http://hdl.handle.net/10541/95808
    DOI
    10.3109/10715769609088005
    PubMed ID
    8845917
    Type
    Article
    Language
    en
    ISSN
    1071-5762
    ae974a485f413a2113503eed53cd6c53
    10.3109/10715769609088005
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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