Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease.
Affiliation
University Department of Dermatology, Western Infirmary, Glasgow, U.K.Issue Date
1996-11
Metadata
Show full item recordAbstract
The efficacy and suitability of photodynamic therapy (PDT) was compared with that of cryotherapy in the treatment of 40 lesions of Bowen's disease. Lesions were randomized to receive either cryotherapy with liquid nitrogen, or PDT using a portable desktop lamp incorporating a 300 W xenon short arc discharge source. A porphyrin precursor, 5-aminolaevulinic acid (5-ALA), was applied topically 4 h before irradiation in the PDT group. Each lesion received 125 J/cm2 at a fluence rate of 70 mW/cm2. All patients were reviewed at 2-monthly intervals and treatments repeated if required. Cryotherapy produced clearance in 10 of 20 lesions after one treatment, the remaining 10 lesions requiring two or three treatment applications. PDT resulted in clearance of 15 of 20 lesions after one treatment and of the remaining five lesions after a second treatment. The probability that a lesion cleared after one treatment was greater with PDT than cryotherapy (P < 0.01). Cryotherapy was associated with ulceration (five of 20), infection (two of 20) and recurrent disease (two of 20); no such complications occurred following PDT. PDT using a non-laser light source and topical 5-ALA appears to be at least as effective as cryotherapy in the treatment of Bowen's disease with fewer adverse effects.Citation
Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease. 1996, 135 (5):766-71 Br. J. Dermatol.Journal
The British Journal of DermatologyDOI
10.1046/j.1365-2133.1996.d01-1076.xPubMed ID
8977678Type
ArticleLanguage
enISSN
0007-0963ae974a485f413a2113503eed53cd6c53
10.1046/j.1365-2133.1996.d01-1076.x
Scopus Count
Collections
Related articles
- Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5-aminolaevulinic acid phototherapy.
- Authors: Britton JE, Goulden V, Stables G, Stringer M, Sheehan-Dare R
- Issue date: 2005 Oct
- Interventions for cutaneous Bowen's disease.
- Authors: Bath-Hextall FJ, Matin RN, Wilkinson D, Leonardi-Bee J
- Issue date: 2013 Jun 24
- Comparison of the efficacy of ALA-PDT using an excimer-dye laser (630 nm) and a metal-halide lamp (600 to 740 nm) for treatment of Bowen's disease.
- Authors: Mizutani K, Akita Y, Yanagishita T, Kimura M, Tanaka T, Kinoshita Y, Nakano A, Tamada Y, Matsumoto Y, Watanabe D
- Issue date: 2012 Jun
- Large patches of Bowen's disease treated by topical aminolaevulinic acid photodynamic therapy.
- Authors: Stables GI, Stringer MR, Robinson DJ, Ash DV
- Issue date: 1997 Jun
- Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.
- Authors: Morton CA, Whitehurst C, McColl JH, Moore JV, MacKie RM
- Issue date: 2001 Mar