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    Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation.

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    Authors
    Sproston, Anthony R
    Boyle, John M
    Heighway, Jim
    Birch, Jillian M
    Scott, David
    Affiliation
    CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1996-08
    
    Metadata
    Show full item record
    Abstract
    A group of adult skin fibroblast cultures from four individuals representing Li-Fraumeni families with different mutations in the p53 gene were found to be resistant to low dose-rate (0.011 Gy per min) 60Co radiation when compared with a control group of four cultures from normal individuals. The Li-Fraumeni fibroblasts, which could not be distinguished from controls after high dose rate (1.07 Gy per min) irradiation, were shown to be heterozygous (+/mut) at the p53 locus at the time of irradiation.
    Citation
    Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation. 1996, 70 (2):145-50 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/95673
    DOI
    10.1080/095530096145139
    PubMed ID
    8794843
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/095530096145139
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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