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dc.contributor.authorHoyes, Katherine Pen
dc.contributor.authorBingham, Den
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorHarrison, J Den
dc.contributor.authorSharma, Harbans Len
dc.contributor.authorMorris, Ian Den
dc.date.accessioned2010-04-06T09:28:07Z
dc.date.available2010-04-06T09:28:07Z
dc.date.issued1996-10
dc.identifier.citationTransferrin-mediated uptake of plutonium by spermatogenic tubules. 1996, 70 (4):467-71 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002
dc.identifier.pmid8862458
dc.identifier.doi10.1080/095530096144941
dc.identifier.urihttp://hdl.handle.net/10541/95604
dc.description.abstractUsing isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshEndocytosis
dc.subject.meshEpithelium
dc.subject.meshGap Junctions
dc.subject.meshHumans
dc.subject.meshIodine Radioisotopes
dc.subject.meshMale
dc.subject.meshPlutonium
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshSeminiferous Tubules
dc.subject.meshTransferrin
dc.titleTransferrin-mediated uptake of plutonium by spermatogenic tubules.en
dc.typeArticleen
dc.contributor.departmentSchool of Biological Sciences, University of Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen
html.description.abstractUsing isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.


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