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    Transferrin-mediated uptake of plutonium by spermatogenic tubules.

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    Authors
    Hoyes, Katherine P
    Bingham, D
    Hendry, Jolyon H
    Harrison, J D
    Sharma, Harbans L
    Morris, Ian D
    Affiliation
    School of Biological Sciences, University of Manchester, UK.
    Issue Date
    1996-10
    
    Metadata
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    Abstract
    Using isolated rat seminiferous tubules as an in vitro model, we have found that 238Pu can cross the blood-tubule barrier and accumulate within tubules in a time dependent manner. Furthermore, similar to 59Fe, tubule 238Pu uptake was inhibited by the addition of excess transferrin, suggesting that plutonium may utilize the physiological iron-transferrin pathway to cross the blood-tubule barrier. However unlike 59Fe, 238Pu was only transiently associated with the tubules, suggesting differences in the intracellular processing of these radionuclides. The assumptions made in the estimation of doses to the human testis from incorporated plutonium are considered.
    Citation
    Transferrin-mediated uptake of plutonium by spermatogenic tubules. 1996, 70 (4):467-71 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/95604
    DOI
    10.1080/095530096144941
    PubMed ID
    8862458
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/095530096144941
    Scopus Count
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    All Paterson Institute for Cancer Research

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