AffiliationDepartment of Medicine, Hope Hospital, University of Manchester, Salford, UK.
MetadataShow full item record
AbstractApoptosis is a fundamental biological process that regulates cell number and removes cells that are neoplastic or infected by viruses. This review summarises present knowledge of the mechanisms and genetic regulation of apoptosis in the gastrointestinal tract and highlights areas of pharmacological relevance. In the intestine, apoptosis occurs in the crypt and possibly at the villus tip. Abnormal apoptosis plays a role in a number of gastrointestinal disease including colorectal cancer. The effects of cytotoxic drugs, chemical carcinogens, nonsteroidal anti-inflammatory drugs, short-chain fatty acids, bile salts and anthraquinolones on apoptosis in the gastrointestinal tract are reviewed.
CitationApoptosis and gastrointestinal pharmacology. 1996, 72 (2):149-69 Pharmacol. Ther.
JournalPharmacology & Therapeutics
- Apoptosis and gastrointestinal tract.
- Authors: Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza GR
- Issue date: 1999 Mar
- Can nonsteroidal anti-inflammatory drugs favourably affect the alimentary canal?
- Authors: Cichoz-Lach H, Celiński K
- Issue date: 2002
- Necrosis and apoptosis in the gastrointestinal tract.
- Authors: Watson AJ
- Issue date: 1995 Aug
- Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions.
- Authors: Ramachandran A, Madesh M, Balasubramanian KA
- Issue date: 2000 Feb
- Cell death by apoptosis: basic concepts and disease relevance for the gastroenterologist.
- Authors: Que FG, Gores GJ
- Issue date: 1996 Apr