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    Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(I) collagen.

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    Authors
    Travers, H
    French, Neil S
    Norton, John D
    Affiliation
    Cancer Research Campaign, Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital National Health Service Trust, Manchester, United Kingdom.
    Issue Date
    1996-10
    
    Metadata
    Show full item record
    Abstract
    Transformed fibroblasts exhibit reduced adhesion to substrata, a characteristic attributable in part to reduced expression/increased degradation of extracellular matrix (EM) proteins such as type I collagen. To directly assess the role of EM proteins in cellular transformation, a vKRas-transformed mouse fibroblast cell line was transfected with an alpha 2(I) collagen expression construct. Stable transfectants displaying a partial restoration of type I collagen expression showed a flatter morphology with increased adherence to the substratum. These clones also exhibited a reduced ability to clone in soft agar, slower growth kinetics, and suppression of tumorigenicity in nude mice. Restoration of type I collagen is correlated with down-regulation of ras oncogene-responsive NVL3 VL30 gene expression. These results suggest that in addition to suppressing tumorigenicity by promoting cellular adhesion and cytoskeletal organization, EM proteins such as type I collagen may also act to subvert oncoprotein signaling pathways associated with the malignant phenotype.
    Citation
    Suppression of tumorigenicity in Ras-transformed fibroblasts by alpha 2(I) collagen. 1996, 7 (10):1353-60 Cell Growth Differ.
    Journal
    Cell Growth & Differentiation
    URI
    http://hdl.handle.net/10541/95515
    PubMed ID
    8891339
    Type
    Article
    Language
    en
    ISSN
    1044-9523
    Collections
    All Paterson Institute for Cancer Research

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