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dc.contributor.authorBecciolini, A
dc.contributor.authorBalzi, M
dc.contributor.authorFabbrica, D
dc.contributor.authorPotten, Christopher S
dc.date.accessioned2010-04-01T15:32:58Z
dc.date.available2010-04-01T15:32:58Z
dc.date.issued1996-09
dc.identifier.citationCell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day. 1996, 70 (3):281-8 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002
dc.identifier.pmid8800199
dc.identifier.doi10.1080/095530096145012
dc.identifier.urihttp://hdl.handle.net/10541/95511
dc.description.abstractQualitative and quantitative morphological changes in rat jejunum were studied after a whole-body exposure to 3 Gy of gamma rays. Four groups of animals were irradiated at different times of the day, namely midnight, 06.00, 12.00 and 18.00 hours. The number of epithelial cells, labelling and mitotic indices were evaluated in crypt sections and the spatial distribution of S-phase cells was determined. At 12 h after irradiation a marked reduction was observed in all parameters, but the proliferative activity was restored quickly and at 36 h after irradiation the values were significantly higher than the controls. The frequency distribution of labelled cells at different positions in the crypt was reduced at 12 h but a clear expansion of S phase cells to positions near to the crypt villus junction was observed during the recovery phase. The animals irradiated at different times of the day showed a similar general post-irradiation response in the number of cells along the side of the crypt, labelling and mitotic indices and in the distribution of S phase cells along the crypts. It is worth noting that the animals exposed at midnight had a distribution of S phase cells similar to controls at 72 h post-irradiation, i.e. earlier than the other groups.
dc.language.isoenen
dc.subject.meshAnimals
dc.subject.meshCell Division
dc.subject.meshEpithelium
dc.subject.meshFemale
dc.subject.meshGamma Rays
dc.subject.meshIntestine, Small
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshTime Factors
dc.titleCell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Physiopathology, University of Florence, Italy.en
dc.identifier.journalInternational Journal of Radiation Biologyen
html.description.abstractQualitative and quantitative morphological changes in rat jejunum were studied after a whole-body exposure to 3 Gy of gamma rays. Four groups of animals were irradiated at different times of the day, namely midnight, 06.00, 12.00 and 18.00 hours. The number of epithelial cells, labelling and mitotic indices were evaluated in crypt sections and the spatial distribution of S-phase cells was determined. At 12 h after irradiation a marked reduction was observed in all parameters, but the proliferative activity was restored quickly and at 36 h after irradiation the values were significantly higher than the controls. The frequency distribution of labelled cells at different positions in the crypt was reduced at 12 h but a clear expansion of S phase cells to positions near to the crypt villus junction was observed during the recovery phase. The animals irradiated at different times of the day showed a similar general post-irradiation response in the number of cells along the side of the crypt, labelling and mitotic indices and in the distribution of S phase cells along the crypts. It is worth noting that the animals exposed at midnight had a distribution of S phase cells similar to controls at 72 h post-irradiation, i.e. earlier than the other groups.


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