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    Cell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day.

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    Authors
    Becciolini, A
    Balzi, M
    Fabbrica, D
    Potten, Christopher S
    Affiliation
    Department of Clinical Physiopathology, University of Florence, Italy.
    Issue Date
    1996-09
    
    Metadata
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    Abstract
    Qualitative and quantitative morphological changes in rat jejunum were studied after a whole-body exposure to 3 Gy of gamma rays. Four groups of animals were irradiated at different times of the day, namely midnight, 06.00, 12.00 and 18.00 hours. The number of epithelial cells, labelling and mitotic indices were evaluated in crypt sections and the spatial distribution of S-phase cells was determined. At 12 h after irradiation a marked reduction was observed in all parameters, but the proliferative activity was restored quickly and at 36 h after irradiation the values were significantly higher than the controls. The frequency distribution of labelled cells at different positions in the crypt was reduced at 12 h but a clear expansion of S phase cells to positions near to the crypt villus junction was observed during the recovery phase. The animals irradiated at different times of the day showed a similar general post-irradiation response in the number of cells along the side of the crypt, labelling and mitotic indices and in the distribution of S phase cells along the crypts. It is worth noting that the animals exposed at midnight had a distribution of S phase cells similar to controls at 72 h post-irradiation, i.e. earlier than the other groups.
    Citation
    Cell kinetics in rat small intestine after exposure to 3 Gy of gamma-rays at different times of the day. 1996, 70 (3):281-8 Int. J. Radiat. Biol.
    Journal
    International Journal of Radiation Biology
    URI
    http://hdl.handle.net/10541/95511
    DOI
    10.1080/095530096145012
    PubMed ID
    8800199
    Type
    Article
    Language
    en
    ISSN
    0955-3002
    ae974a485f413a2113503eed53cd6c53
    10.1080/095530096145012
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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