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    The intestinal epithelial stem cell: the mucosal governor.

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    Authors
    Potten, Christopher S
    Booth, Catherine
    Pritchard, D M
    Affiliation
    CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. epbcsp@picr.man.ac.uk
    Issue Date
    1997-08
    
    Metadata
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    Abstract
    All epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To-date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred. A range of experimental techniques have been employed including cell position mapping, radiation regeneration (clonogenic) assays, chimeric and transgenic mice. This review discusses the implications of experiments performed using these techniques in order to deduce the number, location and functional properties of stem cells. Stem cell homeostasis is maintained by cell proliferation and death 'through apoptosis'. The various growth and matrix factors and genes which may control these processes, and be important for stem cell function, are discussed along with their carcinogenic and clinical implications.
    Citation
    The intestinal epithelial stem cell: the mucosal governor. 1997, 78 (4):219-43 Int J Exp Pathol
    Journal
    International Journal of Experimental Pathology
    URI
    http://hdl.handle.net/10541/95494
    DOI
    10.1046/j.1365-2613.1997.280362.x
    PubMed ID
    9505935
    Type
    Article
    Language
    en
    ISSN
    0959-9673
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1365-2613.1997.280362.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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