AffiliationCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK. email@example.com
MetadataShow full item record
AbstractAll epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To-date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred. A range of experimental techniques have been employed including cell position mapping, radiation regeneration (clonogenic) assays, chimeric and transgenic mice. This review discusses the implications of experiments performed using these techniques in order to deduce the number, location and functional properties of stem cells. Stem cell homeostasis is maintained by cell proliferation and death 'through apoptosis'. The various growth and matrix factors and genes which may control these processes, and be important for stem cell function, are discussed along with their carcinogenic and clinical implications.
CitationThe intestinal epithelial stem cell: the mucosal governor. 1997, 78 (4):219-43 Int J Exp Pathol
JournalInternational Journal of Experimental Pathology
- A mouse model of intestinal stem cell function and regeneration.
- Authors: Slorach EM, Campbell FC, Dorin JR
- Issue date: 1999 Sep
- Intestinal stem cells protect their genome by selective segregation of template DNA strands.
- Authors: Potten CS, Owen G, Booth D
- Issue date: 2002 Jun 1
- Apoptosis in oral mucosa: lessons from the crypt. A commentary.
- Authors: Potten CS
- Issue date: 2001 Mar
- Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium.
- Authors: Potten CS, Wilson JW, Booth C
- Issue date: 1997
- EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture.
- Authors: Suzuki A, Sekiya S, Gunshima E, Fujii S, Taniguchi H
- Issue date: 2010 Oct