AffiliationCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
MetadataShow full item record
AbstractAlthough there has been much debate about the uptake and effects of predictive testing for common cancers, such as breast and colon cancer, little has been published on the more classical tumour predisposing conditions, such as von Hippel-Lindau disease and familial adenomatous polyposis. Since 1990 the genetics departments in Manchester and Cambridge have had a genetic register for cancer predisposing syndromes and presymptomatic testing for these conditions has been offered once this has become possible. To investigate the factors that might influence uptake of genetic testing in familial cancer syndromes we have reviewed our experience. Demand for predictive testing has generally been high, but men had a lower uptake (77%) than a comparable group of women (93%) (p < 0.01).
CitationUptake of genetic testing for cancer predisposition. 1997, 34 (9):746-8 J. Med. Genet.
JournalJournal of Medical Genetics
- Childhood predictive genetic testing for Li-Fraumeni syndrome.
- Authors: Evans DG, Lunt P, Clancy T, Eeles R
- Issue date: 2010 Mar
- Parent decision-making around the genetic testing of children for germline TP53 mutations.
- Authors: Alderfer MA, Zelley K, Lindell RB, Novokmet A, Mai PL, Garber JE, Nathan D, Scollon S, Chun NM, Patenaude AF, Ford JM, Plon SE, Schiffman JD, Diller LR, Savage SA, Malkin D, Ford CA, Nichols KE
- Issue date: 2015 Jan 15
- Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service.
- Authors: Evans DG, Howard E, Giblin C, Clancy T, Spencer H, Huson SM, Lalloo F
- Issue date: 2010 Feb
- Genetic testing for cancer predisposition.
- Authors: Eng C, Hampel H, de la Chapelle A
- Issue date: 2001
- Endocrine tumors associated with neurofibromatosis type 1, Peutz-Jeghers syndrome and other familial neoplasia syndromes.
- Authors: Kalkan E, Waguespack SG
- Issue date: 2013