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    Multilineage gene expression precedes commitment in the hemopoietic system.

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    Authors
    Hu, M
    Krause, D
    Greaves, M
    Sharkis, S
    Dexter, T Michael
    Heyworth, Clare M
    Enver, T
    Affiliation
    The Leukaemia Research Fund Centre at the Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
    Issue Date
    1997-03-15
    
    Metadata
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    Abstract
    We have tested the hypothesis that multipotential hemopoietic stem and progenitor cells prime several different lineage-affiliated programs of gene activity prior to unilineage commitment and differentiation. Using single cell RT-PCR we show that erythroid (beta-globin) and myeloid (myeloperoxidase) gene expression programs can be initiated by the same cell prior to exclusive commitment to the erythroid or granulocytic lineages. Furthermore, the multipotential state is characterized by the coexpression of several lineage-affiliated cytokine receptors. These data support a model of hemopoietic lineage specification in which unilineage commitment is prefaced by a "promiscuous" phase of multilineage locus activation.
    Citation
    Multilineage gene expression precedes commitment in the hemopoietic system. 1997, 11 (6):774-85 Genes Dev.
    Journal
    Genes & Development
    URI
    http://hdl.handle.net/10541/95475
    DOI
    10.1101/gad.11.6.774
    PubMed ID
    9087431
    Type
    Article
    Language
    en
    ISSN
    0890-9369
    ae974a485f413a2113503eed53cd6c53
    10.1101/gad.11.6.774
    Scopus Count
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    All Paterson Institute for Cancer Research

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