The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review.
Affiliation
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, U.K. epbcsp@picr.cr.man.ac.ukIssue Date
1997-11
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Until fairly recently, investigations into the control of cell production (proliferation) have been the mainstay of studies into the maintenance of mucosal homeostasis and general integrity. However, in addition to proliferation, it is now increasingly evident that programmed cell death, specifically that form of programmed cell death known as apoptosis, is an equally, if not more important, mechanism of regulating mucosal cell number. This review will concentrate on the significance of damage (radiation) induced and spontaneous apoptosis in the maintenance of intestinal epithelial stem cell number and integrity, and its probable link to the level of cancer incidence in the small intestine and colon.Citation
The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review. 1997, 118 (3):473-8 Comp. Biochem. Physiol. B, Biochem. Mol. Biol.Journal
Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular BiologyDOI
10.1016/S0305-0491(97)00219-8PubMed ID
9467859Type
ArticleLanguage
enISSN
1096-4959ae974a485f413a2113503eed53cd6c53
10.1016/S0305-0491(97)00219-8
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