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    The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review.

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    Authors
    Potten, Christopher S
    Booth, Catherine
    Affiliation
    CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, U.K. epbcsp@picr.cr.man.ac.uk
    Issue Date
    1997-11
    
    Metadata
    Show full item record
    Abstract
    Until fairly recently, investigations into the control of cell production (proliferation) have been the mainstay of studies into the maintenance of mucosal homeostasis and general integrity. However, in addition to proliferation, it is now increasingly evident that programmed cell death, specifically that form of programmed cell death known as apoptosis, is an equally, if not more important, mechanism of regulating mucosal cell number. This review will concentrate on the significance of damage (radiation) induced and spontaneous apoptosis in the maintenance of intestinal epithelial stem cell number and integrity, and its probable link to the level of cancer incidence in the small intestine and colon.
    Citation
    The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review. 1997, 118 (3):473-8 Comp. Biochem. Physiol. B, Biochem. Mol. Biol.
    Journal
    Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
    URI
    http://hdl.handle.net/10541/95442
    DOI
    10.1016/S0305-0491(97)00219-8
    PubMed ID
    9467859
    Type
    Article
    Language
    en
    ISSN
    1096-4959
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0305-0491(97)00219-8
    Scopus Count
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    All Paterson Institute for Cancer Research

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