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    Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium.

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    Authors
    Potten, Christopher S
    Wilson, James W
    Booth, Catherine
    Affiliation
    CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, United Kingdom.
    Issue Date
    1997
    
    Metadata
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    Abstract
    In rapidly proliferating tissues the stringent control of cell proliferation and cell death by apoptosis is central to the maintenance of tissue homeostasis. In the gastrointestinal tract most work studying the control of tissue cell number has traditionally focused on the growth factor control of proliferation, and the changes that occur during carcinogenesis. However, in recent years it has become increasingly apparent that the control of apoptosis is also crucial. Apoptosis is an important mechanism for eliminating both excess normal cells and those cells which have sustained damage; therefore maintaining a tissue, i.e., stem cells with preserved DNA integrity. In this review the incidence of apoptosis in the stem cells of both the small and large intestine will be discussed in relation to the expression of a number of apoptosis regulating genes (e.g. p53, Bcl-2, bax) within these cells. The importance of apoptosis as a means of controlling stem cell number (and therefore cellular output) will be addressed, as will the mechanisms by which any alterations to this process may contribute to malignancy.
    Citation
    Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. 1997, 15 (2):82-93 Stem Cells
    Journal
    Stem Cells
    URI
    http://hdl.handle.net/10541/95217
    DOI
    10.1002/stem.150082
    PubMed ID
    9090784
    Type
    Article
    Language
    en
    ISSN
    1066-5099
    ae974a485f413a2113503eed53cd6c53
    10.1002/stem.150082
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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