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    Generation of a contig comprising YACs and BACs within chromosome region 1p13.1.

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    Authors
    Brintnell, Bill
    Hey, Yvonne
    Jones, David
    Hoggard, Nigel
    James, Louise A
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1997-03
    
    Metadata
    Show full item record
    Abstract
    Chromosome region 1p13 is known to show loss of heterozygosity (LOH) in a number of human tumor types, including breast. We have generated a contig comprising YACs and BACs spanning part of 1p13.1 which includes the smallest region of overlapping loss identified in our earlier studies. The contig is anchored to the genetic map by a number of microsatellite markers, and by the use of CEPH YACs. We have excluded a number of candidate genes from this region, and we have oriented the contig with respect to the centromere and a number of other genes and markers on 1p13. This resource will be valuable in mapping the target for LOH in breast and other tumors, and may also be useful for the genetic analysis of other genes or diseases known to map to this region.
    Citation
    Generation of a contig comprising YACs and BACs within chromosome region 1p13.1. 1997, 23 (2):153-7 Somat. Cell Mol. Genet.
    Journal
    Somatic Cell and Molecular Genetics
    URI
    http://hdl.handle.net/10541/95213
    DOI
    10.1007/BF02679974
    PubMed ID
    9330643
    Type
    Article
    Language
    en
    ISSN
    0740-7750
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF02679974
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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