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dc.contributor.authorShuker, D E
dc.contributor.authorMargison, Geoffrey P
dc.date.accessioned2010-03-29T15:09:58Z
dc.date.available2010-03-29T15:09:58Z
dc.date.issued1997-02-01
dc.identifier.citationNitrosated glycine derivatives as a potential source of O6-methylguanine in DNA. 1997, 57 (3):366-9 Cancer Res.en
dc.identifier.issn0008-5472
dc.identifier.pmid9012456
dc.identifier.urihttp://hdl.handle.net/10541/95196
dc.description.abstractThe nitrosated bile acid conjugate N-nitrosoglycocholic acid reacts with DNA to give, rise to several adducts including O6-carboxymethylguanine and, unexpectedly, O6-methylguanine (O6-MG). O6-MG is well established as a toxic and promutagenic lesion and is a substrate for the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. In contrast, O6-carboxymethylguanine is not repaired by this protein. Similar results have been obtained for other nitrosated glycine derivatives, which suggests that O6-MG, which has been observed in DNA from human gastrointestinal tissues, may be derived from intragastric nitrosation of glycine or related compounds.
dc.language.isoenen
dc.subject.meshDNA
dc.subject.meshGlycine
dc.subject.meshGuanine
dc.subject.meshHumans
dc.subject.meshNitrosamines
dc.titleNitrosated glycine derivatives as a potential source of O6-methylguanine in DNA.en
dc.typeArticleen
dc.contributor.departmentMRC Toxicology Unit, Hodgkin Building, University of Leicester, United Kingdom.en
dc.identifier.journalCancer Researchen
html.description.abstractThe nitrosated bile acid conjugate N-nitrosoglycocholic acid reacts with DNA to give, rise to several adducts including O6-carboxymethylguanine and, unexpectedly, O6-methylguanine (O6-MG). O6-MG is well established as a toxic and promutagenic lesion and is a substrate for the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. In contrast, O6-carboxymethylguanine is not repaired by this protein. Similar results have been obtained for other nitrosated glycine derivatives, which suggests that O6-MG, which has been observed in DNA from human gastrointestinal tissues, may be derived from intragastric nitrosation of glycine or related compounds.


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