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    Interstitial photodynamic therapy in the canine prostate.

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    Authors
    Lee, L K
    Whitehurst, Colin
    Chen, Q
    Pantelides, M L
    Hetzel, F W
    Moore, James V
    Affiliation
    CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1997-12
    
    Metadata
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    Abstract
    OBJECTIVE: To determine the depth of tissue destruction and the minimum light dose required for necrosis in interstitial photodynamic therapy (PDT), as a prerequisite for the investigational therapy of patients. MATERIALS AND METHODS: Seven adult beagle dogs were given 2 mg/kg of the photosensitizer Photofrin intravenously and two controls received none. After 24 h, 450 J/cm of 630 nm wavelength laser light was delivered interstitially to the prostate via a 2 cm long diffuser fibre. Seven single-fibre treatments were performed in five sensitized dogs and two single-fibre treatments in the controls. The two remaining sensitized dogs had two fibres placed 10 mm apart within the prostate to determine the coalescence of PDT lesions. The penetration depth of light was measured in all prostates, and after PDT the extent of necrosis was assessed histologically. RESULTS: The mean (standard deviation, SD) radius of PDT destruction around each diffuser was 5.3 (1.4) mm and PDT lesions overlapped in prostates treated with two fibres placed 10 mm apart. There was no observable tissue damage in the controls. The mean (SD) minimum light dose required for PDT necrosis was 84 (64) J/cm2. Differences among animals in the light penetration depth were small, with a mean of 2.14 (0.2) mm, and did not correlate with the depth of necrosis (P = 0.07). Bleeding around the optical diffuser fibre impeded light penetration. CONCLUSION: Interstitial PDT in the canine prostate using Photofrin produced modest volumes of tissue necrosis. The minimum light dose required to induce necrosis was variable because bleeding was unpredictable in relation to the optical fibre.
    Citation
    Interstitial photodynamic therapy in the canine prostate. 1997, 80 (6):898-902 Br J Urol
    Journal
    British Journal of Urology
    URI
    http://hdl.handle.net/10541/95180
    DOI
    10.1046/j.1464-410X.1997.00460.x
    PubMed ID
    9439405
    Type
    Article
    Language
    en
    ISSN
    0007-1331
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1464-410X.1997.00460.x
    Scopus Count
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    All Paterson Institute for Cancer Research

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