Singlet oxygen and superoxide characteristics of a series of novel asymmetric photosensitizers.
AuthorsHaylett, Ann K
McNair, Fiona I
Dodd, Nicholas J F
Truscott, T G
Moore, James V
AffiliationDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
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AbstractThe singlet oxygen quantum yields and superoxide quantum yields for a series of novel compounds based on an asymmetrical protoporphyrin molecule have been examined. Electron spin resonance was used to measure superoxide yield and time resolved luminescence for singlet oxygen. A comparison between these results and previously published cell survival data was carried out. A broad association was found between singlet oxygen quantum yield and clonogenic cell kill.
CitationSinglet oxygen and superoxide characteristics of a series of novel asymmetric photosensitizers. 1997, 112 (2):233-8 Cancer Lett.