In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth.

Authors
Lang, Shona H
West, Catharine M L
Jones, L
Brooks, B
Kasper, C
De Wynter, Erika A
Testa, Nydia G
Affiliation
CRC Department of Experimental Haematology, Christie Hospital, Manchester, UK.
Issue Date
1997

Metadata
Show full item record
Abstract
A study was made of the in vitro effects of recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on breast, prostate, cervix and colon cancers. Tumour growth was assessed using a soft agar clonogenic assay. Stimulation of megakaryocyte numbers was seen in liquid culture following 10 ng/ml PEG-rHuMGDF. The same concentration led to no significant difference in colony-forming efficiencies for 22 of 25 tumour samples. A significant reduction in colony-forming efficiencies was seen for the remaining 3 specimens. These results suggest that PEG-rHuMGDF will not stimulate tumour growth in vivo.
Citation
In vitro effects of recombinant human megakaryocyte growth and development factor on primary human tumour colony growth., 54 (2):141-5 Oncology
Journal
Oncology
URI
http://hdl.handle.net/10541/94924
PubMed ID
9075786
Type
Article
Language
en
ISSN
0030-2414
Collections