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    Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma.

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    Authors
    James, Louise A
    Mitchell, Erika L D
    Menasce, Lia P
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
    Issue Date
    1997-03-06
    
    Metadata
    Show full item record
    Abstract
    Comparative genomic hybridisation has been used to map copy number changes in nine cases of ductal carcinoma in situ of the breast obtained from wax-embedded archive material. A wide variety of abnormalities were detected including gain of regions of 1q, 17q, 19q, 20p and 20q and loss on 13q, 14q, 17p, 16q and 22q. Amplification of areas on 10p, 8q and 20q were also observed. Chromosomal alterations were more frequent in higher grade DCIS and closely resemble those previously detected in invasive breast cancer using the same technique. These data provide strong molecular support for the view that DCIS is a precursor lesion of invasive breast carcinoma.
    Citation
    Comparative genomic hybridisation of ductal carcinoma in situ of the breast: identification of regions of DNA amplification and deletion in common with invasive breast carcinoma. 1997, 14 (9):1059-65 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/94907
    DOI
    10.1038/sj.onc.1200923
    PubMed ID
    9070654
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.onc.1200923
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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