Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer.
Authors
Ellis, P ASaccani-Jotti, G
Clarke, Robert B
Johnston, S R
Anderson, Elizabeth
Howell, Anthony
A'Hern, R
Salter, J
Detre, S
Nicholson, R
Robertson, J
Smith, I E
Dowsett, M
Affiliation
Department of Biochemical Endocrinology, Royal Marsden NHS Trust, London, UK.Issue Date
1997-08-07
Metadata
Show full item recordAbstract
Hormonal breast cancer therapies have traditionally been considered cytostatic, but recent pre-clinical data suggest that anti-oestrogens can induce apoptosis. The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre-surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non-treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER- tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross-sectional analysis AI was significantly higher in excision biopsies for ICI-treated than NT patients for ER+ but not ER- tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non-steroidal and steroidal anti-oestrogens.Citation
Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer. 1997, 72 (4):608-13 Int. J. CancerJournal
International Journal of Cancer.DOI
10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7PubMed ID
9259399Type
ArticleLanguage
enISSN
0020-7136ae974a485f413a2113503eed53cd6c53
10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7
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