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    Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer.

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    Authors
    Ellis, P A
    Saccani-Jotti, G
    Clarke, Robert B
    Johnston, S R
    Anderson, Elizabeth
    Howell, Anthony
    A'Hern, R
    Salter, J
    Detre, S
    Nicholson, R
    Robertson, J
    Smith, I E
    Dowsett, M
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    Affiliation
    Department of Biochemical Endocrinology, Royal Marsden NHS Trust, London, UK.
    Issue Date
    1997-08-07
    
    Metadata
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    Abstract
    Hormonal breast cancer therapies have traditionally been considered cytostatic, but recent pre-clinical data suggest that anti-oestrogens can induce apoptosis. The aim of this study was to assess whether tamoxifen (TAM) and ICI 182780 (ICI) could induce apoptosis in human breast cancer, and whether this was related to oestrogen receptor status. We measured apoptosis in primary breast cancer patients before and after pre-surgical treatment with 20 mg/day TAM (study 1) or 6 or 18 mg/day ICI (study 2). In each study there was a randomised non-treatment (NT) control group. TAM significantly increased apoptotic index (AI) in ER+ but not in ER- tumours. There was a significant increase in AI following treatment with ICI. Insufficient pairs of samples were available to determine whether this change was confined to ER+ tumours, but in a cross-sectional analysis AI was significantly higher in excision biopsies for ICI-treated than NT patients for ER+ but not ER- tumours. Our results provide clinical evidence that apoptosis may be induced in ER+ primary breast cancer by both non-steroidal and steroidal anti-oestrogens.
    Citation
    Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer. 1997, 72 (4):608-13 Int. J. Cancer
    Journal
    International Journal of Cancer.
    URI
    http://hdl.handle.net/10541/94898
    DOI
    10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7
    PubMed ID
    9259399
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/(SICI)1097-0215(19970807)72:4<608::AID-IJC10>3.0.CO;2-7
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