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Adenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.

dc.contributor.authorWallis, N T
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorEyden, Brian P
dc.contributor.authorArmstrong, G
dc.date.accessioned2010-03-24T14:06:31Z
dc.date.available2010-03-24T14:06:31Z
dc.date.issued1997-10
dc.identifier.citationAdenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations. 1997, 31 (4):374-7 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid9363454
dc.identifier.doi10.1046/j.1365-2559.1997.2700863.x
dc.identifier.urihttp://hdl.handle.net/10541/94850
dc.description.abstractAIMS: The histological, immunohistochemical and electron microscopic features of a primary adenomyoepithelioma of skin, a rare sweat gland tumour, are reported. METHODS AND RESULTS: The tumour occurred on the back of a 92-year-old woman. It was composed of well-formed tubules lined by epithelial cells surrounded by clear or spindled myoepithelial cells. Immunohistochemically, the epithelial cells exhibited strong cytokeratin (CAM5.2) and weak carcinoembryonic antigen positivity. The myoepithelial cells showed diffuse positivity for smooth muscle actin and focal positivity for S100 protein. Ultrastructurally, the myoepithelial cells contained myofilaments with focal densities and hemidesmosomes. They were limited by well-formed basal lamina. The tumour was associated with a small eccrine spiradenoma. CONCLUSION: We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.
dc.language.isoenen
dc.subjectSweat Gland Canceren
dc.subject.meshActins
dc.subject.meshAdenomyoma
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMicroscopy, Electron
dc.subject.meshMyoepithelioma
dc.subject.meshSweat Gland Neoplasms
dc.titleAdenomyoepithelioma of the skin: a case report with immunohistochemical and ultrastructural observations.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractAIMS: The histological, immunohistochemical and electron microscopic features of a primary adenomyoepithelioma of skin, a rare sweat gland tumour, are reported. METHODS AND RESULTS: The tumour occurred on the back of a 92-year-old woman. It was composed of well-formed tubules lined by epithelial cells surrounded by clear or spindled myoepithelial cells. Immunohistochemically, the epithelial cells exhibited strong cytokeratin (CAM5.2) and weak carcinoembryonic antigen positivity. The myoepithelial cells showed diffuse positivity for smooth muscle actin and focal positivity for S100 protein. Ultrastructurally, the myoepithelial cells contained myofilaments with focal densities and hemidesmosomes. They were limited by well-formed basal lamina. The tumour was associated with a small eccrine spiradenoma. CONCLUSION: We predict that the tumour will behave in a benign fashion. There is no evidence of recurrence or metastasis 28 months later.


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