Effect of low dose oxandrolone and testosterone treatment on the pituitary-testicular and GH axes in boys with constitutional delay of growth and puberty.
Authors
Crowne, Elizabeth CWallace, W Hamish B
Moore, C
Mitchell, R
Robertson, W H
Holly, J M
Shalet, Stephen M
Affiliation
Department of Endocrinology, Christie Hospital Trust, Manchester, UK.Issue Date
1997-02
Metadata
Show full item recordAbstract
OBJECTIVE: To investigate the effect of low dose oxandrolone and testosterone on the pituitary-testicular and GH-IGF-I axes. DESIGN: Prospective double-blind placebo-controlled trial. PATIENTS: Sixteen boys with constitutional delay of growth and puberty (CDGP) with testicular volumes 4-6 ml were randomized to 3 months treatment: Group 1 (n = 5), daily placebo: Group 2 (n = 5), 2.5 mg oxandrolone daily or Group 3 (n = 6), 50 mg testosterone monthly intramuscular injections with assessment (growth, pubertal development and overnight hormone profiles) at 0, 3, 6 and 12 months. MAIN OUTCOME MEASURES: LH and GH profiles (15-minute samples) were analysed by peak detection (Pulsar), Fourier transformation and autocorrelation. Testosterone levels were measured hourly and insulin, SHBG, IGF-I, and IGFBP-3 levels at 0800 h. Statistical analysis was by multivariate analysis of variance for repeated measures. RESULTS: LH and testosterone parameters increased significantly with time in all 16 (LH AUC, P < 0.001; peak amplitude, P = 0.02; number of peaks, P = 0.02; testosterone AUC, P = 0.02; morning testosterone, P = 0.002). In Group 2, however, LH and testosterone parameters decreased at 3 months followed by a rebound increase at 6 and 12 months. SHBG levels were markedly reduced at 3 months (P = 0.006) and a wider range of dominant GH frequencies was present although GH AUC was not increased until 6 months, with an increase in GH pulse frequency but not amplitude. IGF-I levels were increased at both 3 and 12 months. In Group 3, pituitary-testicular suppression was not apparent, but GH levels increased with an increase in GH amplitude at 3 and 12 months. CONCLUSION: Oxandrolone transiently suppressed the pituitary-testicular axis and altered GH pulsatility. Testosterone increased GH via amplitude modulation.Citation
Effect of low dose oxandrolone and testosterone treatment on the pituitary-testicular and GH axes in boys with constitutional delay of growth and puberty. 1997, 46 (2):209-16 Clin. Endocrinol. (Oxf)Journal
Clinical EndocrinologyPubMed ID
9135704Type
ArticleLanguage
enISSN
0300-0664Collections
Related articles
- Degree of activation of the pituitary-testicular axis in early pubertal boys with constitutional delay of growth and puberty determines the growth response to treatment with testosterone or oxandrolone.
- Authors: Crowne EC, Wallace WH, Moore C, Mitchell R, Robertson WR, Shalet SM
- Issue date: 1995 Jun
- The effects of oxandrolone on the growth hormone and gonadal axes in boys with constitutional delay of growth and puberty.
- Authors: Malhotra A, Poon E, Tse WY, Pringle PJ, Hindmarsh PC, Brook CG
- Issue date: 1993 Apr
- Oxandrolone induces a sustained rise in physiological growth hormone secretion in boys with constitutional delay of growth and puberty.
- Authors: Stanhope R, Hindmarsh P, Pringle PJ, Holownia P, Honour J, Brook CG
- Issue date: 1987
- Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys.
- Authors: Wu FC, Brown DC, Butler GE, Stirling HF, Kelnar CJ
- Issue date: 1993 Jan
- Growth and growth hormone responses to oxandrolone in boys with constitutional delay of growth and puberty (CDGP).
- Authors: Clayton PE, Shalet SM, Price DA, Addison GM
- Issue date: 1988 Aug