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dc.contributor.authorSherratt, T
dc.contributor.authorMorelli, C
dc.contributor.authorBoyle, John M
dc.contributor.authorHarrison, Christine J
dc.date.accessioned2010-03-23T17:12:59Z
dc.date.available2010-03-23T17:12:59Z
dc.date.issued1997-04
dc.identifier.citationAnalysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21. 1997, 5 (2):118-24 Chromosome Res.en
dc.identifier.issn0967-3849
dc.identifier.pmid9146915
dc.identifier.doi10.1023/A:1018418224660
dc.identifier.urihttp://hdl.handle.net/10541/94775
dc.description.abstractFluorescence in situ hybridization has been used to define deletion breakpoints within chromosome bands 6q16-21 in cases of lymphoid malignancy. Previous evidence suggested that the region might contain a tumour-suppressor gene. Six yeast artificial chromosome probes, each selected using a single marker, were localized to 6q16-21 and the following order was confirmed; D6S330-D6S283-D6S301-D6S447-D6S246-FYN+ ++. Of 32 cases of lymphoid malignancy, 30 showed deletion of D6S246 and, in the two cases in which D6S246 was retained, the adjacent marker, D6S447, was deleted. These observations imply that a region of minimal deletion is located within a 2-megabase segment of 6q21, between D6S447 and D6S246, providing a candidate region for the location of a tumour-suppressor gene.
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subjectTumour Suppressor Genesen
dc.subjectBiological Tumour Markersen
dc.subject.meshChromosome Deletion
dc.subject.meshChromosome Mapping
dc.subject.meshChromosomes, Artificial, Yeast
dc.subject.meshChromosomes, Human, Pair 6
dc.subject.meshDNA Probes
dc.subject.meshGenes, Tumor Suppressor
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshKaryotyping
dc.subject.meshLymphoma, Non-Hodgkin
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshSequence Tagged Sites
dc.subject.meshTumor Markers, Biological
dc.titleAnalysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cancer Genetics, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalChromosome Researchen
html.description.abstractFluorescence in situ hybridization has been used to define deletion breakpoints within chromosome bands 6q16-21 in cases of lymphoid malignancy. Previous evidence suggested that the region might contain a tumour-suppressor gene. Six yeast artificial chromosome probes, each selected using a single marker, were localized to 6q16-21 and the following order was confirmed; D6S330-D6S283-D6S301-D6S447-D6S246-FYN+ ++. Of 32 cases of lymphoid malignancy, 30 showed deletion of D6S246 and, in the two cases in which D6S246 was retained, the adjacent marker, D6S447, was deleted. These observations imply that a region of minimal deletion is located within a 2-megabase segment of 6q21, between D6S447 and D6S246, providing a candidate region for the location of a tumour-suppressor gene.


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