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    Growth hormone therapy and malignancy.

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    Authors
    Shalet, Stephen M
    Brennan, Bernadette M
    Reddingius, R E
    Affiliation
    Department of Endocrinology, Christie Hospital, Manchester, UK.
    Issue Date
    1997
    
    Metadata
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    Abstract
    The possibility that human growth hormone (GH) replacement therapy might either increase the risk of cancer recurrence in a child who has previously been treated for a brain tumour or leukaemia, or induce de novo cancer, has worried paediatricians for a number of years. Concern arises from animal experiments, the association of acromegaly with malignancy, and the Japanese experience of a cluster of de novo leukaemia cases in children treated with GH. It is reassuring that so far the results from single centre studies and from the pharmaceutical industry surveillance programmes have shown no evidence of an increased risk of malignancy, recurrent or de novo. The confidence intervals, however, are wide and the scientific nature of these studies is flawed as there has never been a prospective randomized study of GH replacement in children with radiation-induced GH deficiency. For clinical reasons, such a study is unlikely to be performed and therefore surveillance must be maintained at a very high level.
    Citation
    Growth hormone therapy and malignancy. 1997, 48 Suppl 4:29-32 Horm. Res.
    Journal
    Hormone Research
    URI
    http://hdl.handle.net/10541/94755
    DOI
    10.1159/000191309
    PubMed ID
    9350443
    Type
    Article
    Language
    en
    ISSN
    0301-0163
    ae974a485f413a2113503eed53cd6c53
    10.1159/000191309
    Scopus Count
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