Affiliation
Department of Endocrinology, Christie Hospital, Manchester, UK.Issue Date
1997
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Show full item recordAbstract
The possibility that human growth hormone (GH) replacement therapy might either increase the risk of cancer recurrence in a child who has previously been treated for a brain tumour or leukaemia, or induce de novo cancer, has worried paediatricians for a number of years. Concern arises from animal experiments, the association of acromegaly with malignancy, and the Japanese experience of a cluster of de novo leukaemia cases in children treated with GH. It is reassuring that so far the results from single centre studies and from the pharmaceutical industry surveillance programmes have shown no evidence of an increased risk of malignancy, recurrent or de novo. The confidence intervals, however, are wide and the scientific nature of these studies is flawed as there has never been a prospective randomized study of GH replacement in children with radiation-induced GH deficiency. For clinical reasons, such a study is unlikely to be performed and therefore surveillance must be maintained at a very high level.Citation
Growth hormone therapy and malignancy. 1997, 48 Suppl 4:29-32 Horm. Res.Journal
Hormone ResearchDOI
10.1159/000191309PubMed ID
9350443Type
ArticleLanguage
enISSN
0301-0163ae974a485f413a2113503eed53cd6c53
10.1159/000191309
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