The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma.
Authors
Cowan, Richard AHoban, Paul R
Kelsey, Anna M
Birch, Jillian M
Gattamaneni, Rao
Evans, D Gareth R
Affiliation
CRC Department of Cancer Genetics, Christie Hospital, Manchester, UK.Issue Date
1997
Metadata
Show full item recordAbstract
Individuals with naevoid basal cell carcinoma (Gorlin) syndrome are at increased risk of developing medulloblastoma in childhood. We have shown that approximately 5% of patients with Gorlin syndrome will develop this complication in the first few years of life, and in addition 10% of patients with medulloblastoma diagnosed at age 2 years or under have Gorlin syndrome. One out of three medulloblastomas occurring in patients with Gorlin syndrome was shown to have lost the wild-type allele on 9q, indicating that the Gorlin locus probably acts as a tumour suppressor in the development of this tumour. We have also confirmed this role in a basal cell carcinoma (BCC) from the same individual. Information from these families would suggest that Gorlin syndrome is more common than previously recognized and may not always be diagnosed on clinical grounds alone even in middle life.Citation
The gene for the naevoid basal cell carcinoma syndrome acts as a tumour-suppressor gene in medulloblastoma. 1997, 76 (2):141-5 Br. J. CancerJournal
British Journal of CancerPubMed ID
9231911Type
ArticleLanguage
enISSN
0007-0920Related articles
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