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dc.contributor.authorShanks, Jonathan H
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorBishop, P W
dc.contributor.authorPearson, J M
dc.contributor.authorEyden, Brian P
dc.date.accessioned2010-03-23T16:04:02Z
dc.date.available2010-03-23T16:04:02Z
dc.date.issued1997-07
dc.identifier.citationNodular erythema elevatum diutinum mimicking cutaneous neoplasms. 1997, 31 (1):91-6 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid9253631
dc.identifier.doi10.1046/j.1365-2559.1997.5840815.x
dc.identifier.urihttp://hdl.handle.net/10541/94723
dc.description.abstractAIMS: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular erythema elevatum diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. METHODS AND RESULTS: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and alpha-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. CONCLUSIONS: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshDiagnosis, Differential
dc.subject.meshErythema Induratum
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshSkin Diseases
dc.subject.meshSkin Neoplasms
dc.titleNodular erythema elevatum diutinum mimicking cutaneous neoplasms.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractAIMS: We describe the cutaneous pseudoneoplastic lesions in two patients with nodular erythema elevatum diutinum, a rare chronic disorder in which polymorph nuclear fragmentation (leukocytoclasis) is present within dermal nodules showing spindle cells and fibrosis. In both cases diagnostic difficulty was encountered clinically and pathologically and various benign and malignant neoplasms were considered in the differential diagnosis. METHODS AND RESULTS: Immunohistochemically the spindle cells were negative for CAM5.2, AE1/3, S100 protein and desmin (D33). They were positive for vimentin and focally positive for CD34 and alpha-smooth muscle actin. Some of the spindle cells were positive for Mac 387 and KP1(CD68). By electron microscopy, the lesions were shown to consist of fibroblasts/myofibroblasts and fusiform macrophages. CONCLUSIONS: Increased awareness of the features described will help to avoid misdiagnosis as a neoplastic process.


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