• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Evans, D Gareth R
    Walsh, S
    Jeacock, J
    Robinson, C
    Hadfield, L
    Davies, D R
    Kingston, R
    Affiliation
    Department of Medical Genetics, St Mary's Hospital, Manchester, UK.
    Issue Date
    1997-09
    
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Previous reports have indicated that 5-13 per cent of colorectal cancer is hereditary. However, the proportion of cases arising as a result of mutations in the hereditary non-polyposis colorectal cancer (HNPCC) genes remains to be determined. METHODS: This study is a part prospective, part retrospective review of all cases of colorectal cancer from a district hospital over 14 years. Some 1137 consecutive patients with colorectal cancer were questioned about their family history of cancer and details were logged on a database. For the past 4 years each case has been re-evaluated where possible. RESULTS: Some 118 patients indicated initially that they had a first-degree relative with colorectal cancer, but on re-evaluation there were significant discrepancies. Only three cases (0.3 per cent) occurred in families which strictly fulfilled the criteria for HNPCC and there were no cases of familial adenomatous polyposis. A total of 16 patients (1.4 per cent) fulfilled looser criteria for HNPCC. CONCLUSION: This population-based study has shown a lower frequency of familial bowel cancer than previous studies and may reflect a lower incidence of inherited mutations in the HNPCC DNA mismatch repair genes than is currently accepted.
    Citation
    Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer. 1997, 84 (9):1281-5 Br J Surg
    Journal
    British Journal of Surgery
    URI
    http://hdl.handle.net/10541/94678
    DOI
    10.1046/j.1365-2168.1997.02781.x
    PubMed ID
    9313714
    Type
    Article
    Language
    en
    ISSN
    0007-1323
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1365-2168.1997.02781.x
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Prophylactic Oophorectomy: Reducing the U.S. Death Rate from Epithelial Ovarian Cancer. A Continuing Debate.
    • Authors: Piver MS
    • Issue date: 1996
    • Patient accuracy of reporting on hereditary non-polyposis colorectal cancer-related malignancy in family members.
    • Authors: Katballe N, Juul S, Christensen M, Ørntoft TF, Wikman FP, Laurberg S
    • Issue date: 2001 Sep
    • A search for germline APC mutations in early onset colorectal cancer or familial colorectal cancer with normal DNA mismatch repair.
    • Authors: Boardman LA, Schmidt S, Lindor NM, Burgart LJ, Cunningham JM, Price-Troska T, Snow K, Ahlquist DA, Thibodeau SN
    • Issue date: 2001 Feb
    • [Hereditary predisposition of colorectal cancer and prevalence of hereditary nonpolyposis colorectal cancer in general population of colorectal cancer patients in China].
    • Authors: Zhang YZ, Sheng JQ, Li SR, Wu ZT
    • Issue date: 2005 Nov 9
    • Risk of gastric cancer in hereditary nonpolyposis colorectal cancer in Korea.
    • Authors: Park YJ, Shin KH, Park JG
    • Issue date: 2000 Aug
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.