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    Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle.

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    Authors
    Jordan, Allan M
    Hadfield, John A
    Lawrence, N J
    McGown, Alan T
    Affiliation
    Department of Chemistry, University of Manchester Institute of Science and Technology, UK.
    Issue Date
    1998-07
    
    Metadata
    Show full item record
    Abstract
    Tubulin is the biochemical target for several clinically used anticancer drugs, including paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the natural and synthetic agents which are known to interact with tubulin. Syntheses of the more complex agents are referenced and the potential clinical use of the compounds is discussed. This review describes the biochemistry of tubulin, microtubules, and the mitotic spindle. The agents are discussed in relation to the type of binding site on the protein with which they interact. These are the colchicine, vinca alkaloid, rhizoxin/maytansine, and tubulin sulfhydryl binding sites. Also included are the agents which either bind at other sites or unknown sites on tubulin. The literature is reviewed up to October 1997.
    Citation
    Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. 1998, 18 (4):259-96 Med Res Rev
    Journal
    Medicinal Research Reviews
    URI
    http://hdl.handle.net/10541/93081
    PubMed ID
    9664292
    Type
    Article
    Language
    en
    ISSN
    0198-6325
    Collections
    All Paterson Institute for Cancer Research

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