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dc.contributor.authorAleksandrzak, Krzysztof
dc.contributor.authorMcGown, Alan T
dc.contributor.authorHadfield, John A
dc.date.accessioned2010-02-25T15:01:00Z
dc.date.available2010-02-25T15:01:00Z
dc.date.issued1998-07
dc.identifier.citationAntimitotic activity of diaryl compounds with structural features resembling combretastatin A-4. 1998, 9 (6):545-50 Anticancer Drugsen
dc.identifier.issn0959-4973
dc.identifier.pmid9877243
dc.identifier.urihttp://hdl.handle.net/10541/93072
dc.description.abstractSeries of diaryl ethers, amines and amides have been synthesized and tested for antitumor activity. These diaryl compounds possess some of the structural features of combretastatin A-4 (a potent antimitotic agent). They were designed to discover whether transferring these structural motifs from stilbenes to heterosubstituted diaryl compounds would enhance their biochemical activities. Molecular modeling studies suggested that these diaryl compounds could adopt conformations similar to combretastatin A-4. However, although some agents (5-7) were cytotoxic and others (10 and 12) could interact with tubulin, none were as potent as combretastatin A-4.
dc.language.isoenen
dc.subjectAntitumour Drug Screening Assaysen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents, Phytogenic
dc.subject.meshBibenzyls
dc.subject.meshDrug Screening Assays, Antitumor
dc.subject.meshLeukemia P388
dc.subject.meshMice
dc.subject.meshStilbenes
dc.subject.meshStructure-Activity Relationship
dc.subject.meshTumor Cells, Cultured
dc.titleAntimitotic activity of diaryl compounds with structural features resembling combretastatin A-4.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drugsen
html.description.abstractSeries of diaryl ethers, amines and amides have been synthesized and tested for antitumor activity. These diaryl compounds possess some of the structural features of combretastatin A-4 (a potent antimitotic agent). They were designed to discover whether transferring these structural motifs from stilbenes to heterosubstituted diaryl compounds would enhance their biochemical activities. Molecular modeling studies suggested that these diaryl compounds could adopt conformations similar to combretastatin A-4. However, although some agents (5-7) were cytotoxic and others (10 and 12) could interact with tubulin, none were as potent as combretastatin A-4.


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