Colonic cell proliferation in normal mucosa of patients with colon cancer.
Authors
Becciolini, ABalzi, M
Faraoni, P
Tisti, E
Zappoli Thyrion, G
Giachè, V
Bandettini, L
Potten, Christopher S
Affiliation
Department of Clinical Physiopathology, University of Florence, Italy.Issue Date
1998
Metadata
Show full item recordAbstract
Cell kinetics parameters have been analysed in colonic mucosa at different distances from a tumour in patients with colon carcinoma. Total cell number (TCN), 3H thymidine labelling index (TLI), mitotic index (MI), Goblet cell index (GCI) and the distribution of labelled cells along the crypt column (cell position frequency plot) were determined in well-aligned crypts. Total cell number, GCI and the labelled cell position frequency plots were similar in different samples from the same individual. A negative linear correlation between TCN and TLI was observed. The analysis of the cell position plots showed two patterns 1) with a high concentration in the bottom fifth of the crypt and 2) with frequent labelled cells at high positions. Whereas a negative correlation between overall TLI and the percent contribution to the TLI of the lowermost fifth was seen, the correlation was positive for the next 3 fifths and labelling was absent in the last part of the crypt.Citation
Colonic cell proliferation in normal mucosa of patients with colon cancer. 1998, 37 (1):65-71 Acta OncolJournal
Acta OncologicaPubMed ID
9572656Type
ArticleLanguage
enISSN
0284-186XCollections
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