Potent antimitotic and cell growth inhibitory properties of substituted chalcones.
AuthorsDucki, Sylvie W
Hadfield, John A
Lawrence, N J
McGown, Alan T
AffiliationDept. of Chemistry, University of Manchester Institute of Science and Technology, UK.
MetadataShow full item record
AbstractA series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
CitationPotent antimitotic and cell growth inhibitory properties of substituted chalcones. 1998, 8 (9):1051-6 Bioorg. Med. Chem. Lett.
JournalBioorganic & Medicinal Chemistry Letters
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