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    Potent antimitotic and cell growth inhibitory properties of substituted chalcones.

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    Authors
    Ducki, Sylvie W
    Forrest, R
    Hadfield, John A
    Kendall, A
    Lawrence, N J
    McGown, Alan T
    Rennison, David
    Affiliation
    Dept. of Chemistry, University of Manchester Institute of Science and Technology, UK.
    Issue Date
    1998-05-05
    
    Metadata
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    Abstract
    A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.
    Citation
    Potent antimitotic and cell growth inhibitory properties of substituted chalcones. 1998, 8 (9):1051-6 Bioorg. Med. Chem. Lett.
    Journal
    Bioorganic & Medicinal Chemistry Letters
    URI
    http://hdl.handle.net/10541/93022
    PubMed ID
    9871706
    Type
    Article
    Language
    en
    ISSN
    0960-894X
    Collections
    All Paterson Institute for Cancer Research

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