• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Marsh, K L
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1998-05
    
    Metadata
    Show full item record
    Abstract
    Progression through G1 phase of the eukaryotic cell cycle is tightly controlled by cyclin-dependent kinases (CDK). These proteins form part of a regulatory pathway including the cyclin-dependent kinase inhibitor (CKI) p16, D-type cyclins and the product of the retinoblastoma gene pRb. Aberration of any one of these components may lead to uncontrolled proliferation contributing to neoplasia. Three of these proteins, cyclin D1, pRb and p16, were analysed by immunohistochemistry on archival paraffin sections to determine whether expression patterns were different in preinvasive ductal carcinoma in situ (DCIS) and invasive breast tumours relative to normal. Genetic analysis of the gene encoding cyclin D1 (CCND1) was also carried out, using an intragenic restriction fragment-length polymorphism (RFLP) to assess possible allelic imbalance. A majority of the tumours studied (approximately 90%) showed abnormalities in expression of at least one of these proteins. Overexpression of cyclin D1 was found in approximately 49% cases, reduced expression of p16 in approximately 46% and reduced expression of pRb in approximately 37%. Allelic imbalance of cyclin D1 was found in approximately 57% cases.
    Citation
    Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry. 1998, 77 (9):1460-8 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/92917
    PubMed ID
    9652762
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Alterations in cyclin D1 expression in esophageal squamous cell carcinoma in the Indian population.
    • Authors: Mathew R, Arora S, Khanna R, Shukla NK, Mathur M, Ralhan R
    • Issue date: 2001 Apr
    • Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein.
    • Authors: Nielsen NH, Emdin SO, Cajander J, Landberg G
    • Issue date: 1997 Jan 23
    • Analysis of p53, p16(INK4a), pRb and Cyclin D1 expression and human papillomavirus in primary ovarian serous carcinomas.
    • Authors: Bilyk OO, Pande NT, Buchynska LG
    • Issue date: 2011 Sep
    • Retinoblastoma and p16 proteins in mammary carcinoma: their relationship to cyclin D1 and histopathological parameters.
    • Authors: Dublin EA, Patel NK, Gillett CE, Smith P, Peters G, Barnes DM
    • Issue date: 1998 Feb 20
    • Changes in expression of pRb, p16 and cyclin D1 in non-small cell lung cancer: an immunohistochemical study.
    • Authors: Malusecka E, Zborek A, Krzyzowska-Gruca S
    • Issue date: 1999
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.