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dc.contributor.authorMarsh, K L
dc.contributor.authorVarley, Jennifer
dc.date.accessioned2010-02-24T13:17:41Z
dc.date.available2010-02-24T13:17:41Z
dc.date.issued1998-05
dc.identifier.citationLoss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast. 1998, 77 (9):1439-47 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid9652759
dc.identifier.urihttp://hdl.handle.net/10541/92916
dc.description.abstractTwenty-three cases of ductal carcinoma in situ (DCIS), ten of which had an associated invasive component, were studied for loss of heterozygosity (LOH) of microsatellite markers on chromosome 9p and the results compared with a panel of 20 invasive breast carcinomas. In addition to the gene encoding p16, chromosome 9p is also thought to contain other putative tumour-suppressor genes. If the three panels of breast tumours showed LOH of markers in this region this would suggest that such putative genes were important in breast carcinogenesis. By studying both preinvasive and invasive breast tumours, it should also be possible to gain further information about the relationship between lesions of a different stage and to determine whether DCIS is indeed a precursor of invasive ductal carcinoma. Levels of LOH were low in the invasive-only set of tumours. Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer DNAen
dc.subjectCancer Invasivenessen
dc.subject.meshBreast Neoplasms
dc.subject.meshCarcinoma in Situ
dc.subject.meshCarcinoma, Ductal, Breast
dc.subject.meshChromosomes, Human, Pair 9
dc.subject.meshDNA, Neoplasm
dc.subject.meshFemale
dc.subject.meshGenetic Markers
dc.subject.meshHumans
dc.subject.meshLoss of Heterozygosity
dc.subject.meshNeoplasm Invasiveness
dc.titleLoss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractTwenty-three cases of ductal carcinoma in situ (DCIS), ten of which had an associated invasive component, were studied for loss of heterozygosity (LOH) of microsatellite markers on chromosome 9p and the results compared with a panel of 20 invasive breast carcinomas. In addition to the gene encoding p16, chromosome 9p is also thought to contain other putative tumour-suppressor genes. If the three panels of breast tumours showed LOH of markers in this region this would suggest that such putative genes were important in breast carcinogenesis. By studying both preinvasive and invasive breast tumours, it should also be possible to gain further information about the relationship between lesions of a different stage and to determine whether DCIS is indeed a precursor of invasive ductal carcinoma. Levels of LOH were low in the invasive-only set of tumours. Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case.


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