AffiliationCancer Research Campaign Dept of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. JNorton@picr.man.ac.uk
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AbstractId helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed.
CitationId helix-loop-helix proteins in cell growth and differentiation. 1998, 8 (2):58-65 Trends Cell Biol.
JournalTrends in Cell Biology
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