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    Id helix-loop-helix proteins in cell growth and differentiation.

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    Authors
    Norton, John D
    Deed, Richard W
    Craggs, Graham
    Sablitzky, F
    Affiliation
    Cancer Research Campaign Dept of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK. JNorton@picr.man.ac.uk
    Issue Date
    1998-02
    
    Metadata
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    Abstract
    Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linked gene expression with cell-cycle control in response to extracellular signalling are reviewed.
    Citation
    Id helix-loop-helix proteins in cell growth and differentiation. 1998, 8 (2):58-65 Trends Cell Biol.
    Journal
    Trends in Cell Biology
    URI
    http://hdl.handle.net/10541/92757
    PubMed ID
    9695810
    Type
    Article
    Language
    en
    ISSN
    0962-8924
    Collections
    All Paterson Institute for Cancer Research

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