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dc.contributor.authorCooper, Rachel A
dc.contributor.authorWilks, Deepti P
dc.contributor.authorLogue, John P
dc.contributor.authorDavidson, Susan E
dc.contributor.authorHunter, Robin D
dc.contributor.authorRoberts, Stephen A
dc.contributor.authorWest, Catharine M L
dc.date.accessioned2010-02-12T16:27:01Z
dc.date.available2010-02-12T16:27:01Z
dc.date.issued1998-11
dc.identifier.citationHigh tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy. 1998, 4 (11):2795-800 Clin. Cancer Res.en
dc.identifier.issn1078-0432
dc.identifier.pmid9829744
dc.identifier.urihttp://hdl.handle.net/10541/92041
dc.description.abstractThe purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A retrospective study was carried out on 111 patients. Formalin-fixed, paraffin-embedded tumor biopsies were stained with anti-factor VIII using immunohistochemistry. Tumor angiogenesis was assessed by scoring the distance to the closest microvessel from random points within the tumor and the intratumor microvessel density (IMD) in the areas of highest neovascularization. High vascularity, as measured by both methods, was associated with a poor prognosis but was only significant for IMD. The 5-year survival rates for tumors with high versus low values were 50 and 65%, respectively. IMD was a significant prognostic factor within a Cox multivariate analysis. Higher tumor vascularity was associated with lower overall survival and locoregional control, but this association was not significant in the case of metastasis-free survival. The method used to assess tumor vascularity is important. The level of angiogenesis in carcinoma of the cervix is an independent prognostic parameter.
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdenocarcinoma
dc.subject.meshAnalysis of Variance
dc.subject.meshCarcinoma, Squamous Cell
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshMultivariate Analysis
dc.subject.meshNeovascularization, Pathologic
dc.subject.meshOutcome Assessment (Health Care)
dc.subject.meshPrognosis
dc.subject.meshReproducibility of Results
dc.subject.meshSurvival Analysis
dc.subject.meshUterine Cervical Neoplasms
dc.titleHigh tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, United Kingdom.en
dc.identifier.journalClinical Cancer Researchen
html.description.abstractThe purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A retrospective study was carried out on 111 patients. Formalin-fixed, paraffin-embedded tumor biopsies were stained with anti-factor VIII using immunohistochemistry. Tumor angiogenesis was assessed by scoring the distance to the closest microvessel from random points within the tumor and the intratumor microvessel density (IMD) in the areas of highest neovascularization. High vascularity, as measured by both methods, was associated with a poor prognosis but was only significant for IMD. The 5-year survival rates for tumors with high versus low values were 50 and 65%, respectively. IMD was a significant prognostic factor within a Cox multivariate analysis. Higher tumor vascularity was associated with lower overall survival and locoregional control, but this association was not significant in the case of metastasis-free survival. The method used to assess tumor vascularity is important. The level of angiogenesis in carcinoma of the cervix is an independent prognostic parameter.


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