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    High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy.

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    Authors
    Cooper, Rachel A
    Wilks, Deepti P
    Logue, John P
    Davidson, Susan E
    Hunter, Robin D
    Roberts, Stephen A
    West, Catharine M L
    Affiliation
    Cancer Research Campaign Section of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, United Kingdom.
    Issue Date
    1998-11
    
    Metadata
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    Abstract
    The purpose of this study was to examine the relationship between tumor angiogenesis and prognosis in carcinoma of the cervix treated with radiotherapy with a median follow-up time of 55 months. A retrospective study was carried out on 111 patients. Formalin-fixed, paraffin-embedded tumor biopsies were stained with anti-factor VIII using immunohistochemistry. Tumor angiogenesis was assessed by scoring the distance to the closest microvessel from random points within the tumor and the intratumor microvessel density (IMD) in the areas of highest neovascularization. High vascularity, as measured by both methods, was associated with a poor prognosis but was only significant for IMD. The 5-year survival rates for tumors with high versus low values were 50 and 65%, respectively. IMD was a significant prognostic factor within a Cox multivariate analysis. Higher tumor vascularity was associated with lower overall survival and locoregional control, but this association was not significant in the case of metastasis-free survival. The method used to assess tumor vascularity is important. The level of angiogenesis in carcinoma of the cervix is an independent prognostic parameter.
    Citation
    High tumor angiogenesis is associated with poorer survival in carcinoma of the cervix treated with radiotherapy. 1998, 4 (11):2795-800 Clin. Cancer Res.
    Journal
    Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/92041
    PubMed ID
    9829744
    Type
    Article
    Language
    en
    ISSN
    1078-0432
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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