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    O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

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    Authors
    Middleton, Mark R
    Lunn, J M
    Morris, Charles
    Rustin, G
    Wedge, S R
    Brampton, M H
    Lind, Michael J
    Lee, Siow Ming
    Newell, D R
    Bleehen, N M
    Newlands, E S
    Calvert, A H
    Margison, Geoffrey P
    Thatcher, Nick
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    Affiliation
    Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1998-11
    
    Metadata
    Show full item record
    Abstract
    Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biopsies of cutaneous tumours and involved lymph nodes and clinical response to the drug has been studied. Among 50 evaluable patients, there were three complete responses (CR), four partial responses (PR), six with stable disease (SD) and 37 with progressive disease (PD), with an overall response rate of 14%. In 33 patients in whom MGMT level and clinical response could be evaluated, the tumour MGMT levels (fmol mg(-1) protein) were: CR, 158 +/- 119; PR, 607 +/- 481; NC, 171 +/- 101; PD, 185 +/- 42.3. Thus, measurements of pretreatment levels of MGMT in melanoma did not predict for response to temozolomide.
    Citation
    O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma. 1998, 78 (9):1199-202 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/92028
    PubMed ID
    9820180
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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