AuthorsWest, Catharine M L
Davidson, Susan E
Elyan, S A
Roberts, Stephen A
Orton, C J
Coyle, C A
Valentine, Helen R
Wilks, Deepti P
Hunter, Robin D
Hendry, Jolyon H
AffiliationCRC Sections of Genome Damage and Repair, Paterson Institute for Cancer Research, Manchester, UK.
MetadataShow full item record
AbstractPURPOSE: To examine whether in vitro measurements of normal and tumour cell radiosensitivity can be used as prognostic factors in clinical oncology. MATERIALS AND METHODS: Stage I-III cervix carcinoma patients were treated with radical radiotherapy with a minimum of 3 years' follow-up. Lymphocyte and tumour radiosensitivities were assayed using, respectively, a limiting dilution and soft agar clonogenic assay to obtain surviving fraction at 2 Gy (SF2). The results were related, in an actuarial analysis, to late morbidity assessed using the Franco Italian glossary. RESULTS: Patients with radiosensitive lymphocytes had a significantly increased risk of developing late complications (n = 93, p = 0.002). Increasing tumour radiosensitivity was associated with an increased risk of morbidity (n= 113, p=0.032). A significant correlation was found between fibroblast and tumour cell radiosensitivity (r=0.57, p=0.03), but a weak inverse association was found between lymphocyte and tumour cell radiosensitivity (r= -0.32, p=0.03). Patients with radiosensitive lymphocytes and tumour cells had higher levels of late complications than those whose cells were radioresistant. CONCLUSION: The work described highlights the importance of cellular radiosensitivity as a parameter determining the clinical response to radiotherapy.
CitationThe intrinsic radiosensitivity of normal and tumour cells. 1998, 73 (4):409-13 Int. J. Radiat. Biol.
JournalInternational Journal of Radiation Biology
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- Authors: West CM, Davidson SE, Elyan SA, Valentine H, Roberts SA, Swindell R, Hunter RD
- Issue date: 2001 Sep 1
- Relationship between tumour cell in vitro radiosensitivity and clinical outcome after curative radiotherapy for squamous cell carcinoma of the head and neck.
- Authors: Stausbøl-Grøn B, Overgaard J
- Issue date: 1999 Jan
- Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix.
- Authors: West CM, Davidson SE, Roberts SA, Hunter RD
- Issue date: 1993 Oct
- Pretreatment plasma TGF beta 1 levels are prognostic for survival but not morbidity following radiation therapy of carcinoma of the cervix.
- Authors: Dickson J, Davidson SE, Hunter RD, West CM
- Issue date: 2000 Nov 1
- In vitro radiosensitivity of tumour cells and fibroblasts derived from head and neck carcinomas: mutual relationship and correlation with clinical data.
- Authors: Stausbøl-Grøn B, Bentzen SM, Jørgensen KE, Nielsen OS, Bundgaard T, Overgaard J
- Issue date: 1999 Mar