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dc.contributor.authorIczkowski, K A
dc.contributor.authorShanks, Jonathan H
dc.contributor.authorBostwick, D G
dc.date.accessioned2010-02-12T15:10:51Z
dc.date.available2010-02-12T15:10:51Z
dc.date.issued1998-04
dc.identifier.citationLoss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma. 1998, 32 (4):322-7 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid9602328
dc.identifier.doi10.1046/j.1365-2559.1998.00398.x
dc.identifier.urihttp://hdl.handle.net/10541/92017
dc.description.abstractAIMS: Small cell carcinoma of the urinary bladder has a more aggressive biological potential than urothelial carcinoma, but its morphology may overlap with poorly differentiated urothelial carcinoma. The CD44 family of glycoproteins mediates cell-cell and cell-matrix adhesion. Aberrant regulation of expression of CD44, and particularly its v6 variant exon, has been correlated with aggressive or metastatic phenotype of some cancers. We measured the degree of protein expression of CD44v6 in small cell and urothelial bladder carcinoma. METHOD AND RESULTS: Immunohistochemical staining was performed with monoclonal antibodies against CD44v6. Immunoreactivity was absent in 25 of 27 cases of small cell carcinoma, with two showing only weak staining of fewer than 10% of cells. In contrast, all 12 cases of moderately or poorly differentiated urothelial carcinoma displayed moderately intense reactivity in 50% to 100% of cells. CONCLUSIONS: CD44v6 immunostaining discriminates cases of poorly differentiated urothelial carcinoma from small cell carcinoma. It also highlights the presence of mixed small cell urothelial differentiation when present.
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAged
dc.subject.meshAntigens, CD44
dc.subject.meshCarcinoma, Small Cell
dc.subject.meshCarcinoma, Transitional Cell
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshGlycoproteins
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshMale
dc.subject.meshUrinary Bladder Neoplasms
dc.subject.meshUrothelium
dc.titleLoss of CD44 variant 6 expression differentiates small cell carcinoma of urinary bladder from urothelial (transitional cell) carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Mayo Clinic, Rochester, Minnesota, USA.en
dc.identifier.journalHistopathologyen
html.description.abstractAIMS: Small cell carcinoma of the urinary bladder has a more aggressive biological potential than urothelial carcinoma, but its morphology may overlap with poorly differentiated urothelial carcinoma. The CD44 family of glycoproteins mediates cell-cell and cell-matrix adhesion. Aberrant regulation of expression of CD44, and particularly its v6 variant exon, has been correlated with aggressive or metastatic phenotype of some cancers. We measured the degree of protein expression of CD44v6 in small cell and urothelial bladder carcinoma. METHOD AND RESULTS: Immunohistochemical staining was performed with monoclonal antibodies against CD44v6. Immunoreactivity was absent in 25 of 27 cases of small cell carcinoma, with two showing only weak staining of fewer than 10% of cells. In contrast, all 12 cases of moderately or poorly differentiated urothelial carcinoma displayed moderately intense reactivity in 50% to 100% of cells. CONCLUSIONS: CD44v6 immunostaining discriminates cases of poorly differentiated urothelial carcinoma from small cell carcinoma. It also highlights the presence of mixed small cell urothelial differentiation when present.


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