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    Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer.

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    Authors
    Pendleton, N
    Pazouki, S
    Heerkens, E
    Smither, Rachel L
    Chisholm, D M
    Moore, James V
    Howell, Anthony
    Horan, M A
    Schor, Ana M
    Affiliation
    University Department of Geriatric Medicine, Hope Hospital, Salford, U.K.
    Issue Date
    1998
    
    Metadata
    Show full item record
    Abstract
    Microvascular density has been put forward as an independent prognostic factor in breast cancer, with high levels indicating poorer prognosis. However, various studies have failed to confirm its prognostic value. The reasons for the contradictory results are not known, but it is believed that methodological differences are responsible. To test this hypothesis, we have used four different methods of assessing vascularity (average and highest microvascular density, microvascular volume and image analysis of vascular area) and related them to known prognostic factors in 51 cases of breast cancer NOS. All four methods showed a significant correlation with each other, with the exception of image analysis vs microvascular volume. The average microvascular density was significantly lower in p53 positive compared to negative tumours (median 38.4 and 66.2; IQR 31.1 and 49.4, respectively, p < 0.05). Vascularity, measured by the four methods, was not associated with nodal status or any other parameter examined.
    Citation
    Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer., 18 (6B):4565-8 Anticancer Res.
    Journal
    Anticancer Research
    URI
    http://hdl.handle.net/10541/92010
    PubMed ID
    9891519
    Type
    Article
    Language
    en
    ISSN
    0250-7005
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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