Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer.
Authors
Pendleton, NPazouki, S
Heerkens, E
Smither, Rachel L
Chisholm, D M
Moore, James V
Howell, Anthony
Horan, M A
Schor, Ana M
Affiliation
University Department of Geriatric Medicine, Hope Hospital, Salford, U.K.Issue Date
1998
Metadata
Show full item recordAbstract
Microvascular density has been put forward as an independent prognostic factor in breast cancer, with high levels indicating poorer prognosis. However, various studies have failed to confirm its prognostic value. The reasons for the contradictory results are not known, but it is believed that methodological differences are responsible. To test this hypothesis, we have used four different methods of assessing vascularity (average and highest microvascular density, microvascular volume and image analysis of vascular area) and related them to known prognostic factors in 51 cases of breast cancer NOS. All four methods showed a significant correlation with each other, with the exception of image analysis vs microvascular volume. The average microvascular density was significantly lower in p53 positive compared to negative tumours (median 38.4 and 66.2; IQR 31.1 and 49.4, respectively, p < 0.05). Vascularity, measured by the four methods, was not associated with nodal status or any other parameter examined.Citation
Relationships between different measurements of vascularity and clinico-pathological parameters in breast cancer., 18 (6B):4565-8 Anticancer Res.Journal
Anticancer ResearchPubMed ID
9891519Type
ArticleLanguage
enISSN
0250-7005Related articles
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