Predictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix.
AffiliationDepartment of Diagnostic Radiology, Victoria University of Manchester Medical School, UK.
MetadataShow full item record
AbstractThe objectives of this study were to compare tumour staging and volume assessment by examination under anaesthesia (EUA), transrectal ultrasound (TRU) and magnetic resonance imaging (MRI) in patients with invasive carcinoma of the cervix, and to correlate findings with long-term outcome following treatment by radiotherapy. Tumour staging was performed on 60 patients immediately before starting radiotherapy. Clinicians and radiologists performing EUA, TRU or MRI were blinded to the results of other investigations. Tumour stage and dimensions were recorded prospectively for each technique, and analysed for concordance. The relationship between pre-treatment stage, size of tumour and patient outcome after radiotherapy was assessed, using clinical status 5 years after treatment as the truth measure. EUA, TRU and MRI assigned the same tumour stage in only 30% of patients and EUA and MRI agreed tumour stage in a further 27%. In cases of disagreement, the MRI stage correlated better with outcome than the TRU or EUA stage. There was a significant difference between tumour volume obtained from measurements made on MRI and those from TRU. 62% of patients with enlarged lymph nodes on pre-treatment MRI either died, or developed tumour recurrence or metastases. The ability of MRI to assess the full extent of bulky tumours and the presence of lymph node enlargement was an advantage over both EUA and TRU in identifying patients with a poor prognosis.
CitationPredictive value of clinical examination, transrectal ultrasound and magnetic resonance imaging prior to radiotherapy in carcinoma of the cervix. 1998, 71 (848):819-27 Br J Radiol
JournalBritish Journal of Radiology
- Magnetic resonance imaging, computed tomography and endosonography in the local staging of carcinoma of the cervix.
- Authors: Cobby M, Browning J, Jones A, Whipp E, Goddard P
- Issue date: 1990 Sep
- Transrectal ultrasound in the evaluation of cervical carcinoma and comparison with spiral computed tomography and magnetic resonance imaging.
- Authors: Yang WT, Walkden SB, Ho S, Cheung TH, Lam SK, Teo J, Metreweli C
- Issue date: 1996 Jul
- Staging of advanced cervical carcinoma using MRI-predictors of outcome after radical radiotherapy.
- Authors: Taylor MB, Carrington BM, Davidson SE, Swindell R, Lawrance JA
- Issue date: 2003 Jul
- Tumor diameter and volume assessed by magnetic resonance imaging in the prediction of outcome for invasive cervical cancer.
- Authors: Wagenaar HC, Trimbos JB, Postema S, Anastasopoulou A, van der Geest RJ, Reiber JH, Kenter GG, Peters AA, Pattynama PM
- Issue date: 2001 Sep
- Pretreatment tumour volume measurement on high-resolution magnetic resonance imaging as a predictor of survival in cervical cancer.
- Authors: Soutter WP, Hanoch J, D'Arcy T, Dina R, McIndoe GA, DeSouza NM
- Issue date: 2004 Jul