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    Schwannoma with features mimicking neuroblastoma: report of two cases with immunohistochemical and ultrastructural findings.

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    Authors
    Bhatnagar, S
    Banerjee, Saumitra S
    Mene, A R
    Prescott, R J
    Eyden, Brian P
    Affiliation
    Department of Pathology, Christie Hospital, Manchester, UK.
    Issue Date
    1998-11
    
    Metadata
    Show full item record
    Abstract
    OBJECTIVE: A study of two cases of a rare variant of benign schwannoma showing areas mimicking neuroblastoma/peripheral primitive neuroectodermal tumour (PNET). METHODS: Sections of formalin fixed, paraffin embedded specimens were studied by tinctorial stains and immunohistochemistry, and the tissue retrieved from formalin was examined by electronmicroscopy in one case. RESULTS: The tumours were small and subcutaneous. Both showed features of benign schwannoma; one had a multinodular plexiform pattern. In addition, rosette-like structures consisting of collagenous cores surrounded by small round cells or slightly larger epithelioid cells were present. Tumour cells were positive for S100 protein, Leu7, and in one case GFAP, but were negative for neurofilament protein, synaptophysin, and MIC2. Type IV collagen surrounded individual cells. Electronmicroscopy in case 2 confirmed schwannian features (lamina, processes) and failed to show features of neuroblastoma (neuroendocrine granules). CONCLUSIONS: Benign schwannomas may contain rosette-like structures mimicking neuroblastoma/PNET. The techniques used confirmed schwannian differentiation only and eliminated neuroblastoma/PNET. These uncommon variants should be recognised by practising histopathologists to avoid erroneous diagnoses and inappropriate treatment.
    Citation
    Schwannoma with features mimicking neuroblastoma: report of two cases with immunohistochemical and ultrastructural findings. 1998, 51 (11):842-5 J. Clin. Pathol.
    Journal
    Journal of Clinical Pathology
    URI
    http://hdl.handle.net/10541/91925
    DOI
    10.1136/jcp.51.11.842
    PubMed ID
    10193326
    Type
    Article
    Language
    en
    ISSN
    0021-9746
    ae974a485f413a2113503eed53cd6c53
    10.1136/jcp.51.11.842
    Scopus Count
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