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dc.contributor.authorEyden, Brian P
dc.contributor.authorManson, C M
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorRoberts, I S
dc.contributor.authorHarris, Martin
dc.date.accessioned2010-02-11T16:59:53Z
dc.date.available2010-02-11T16:59:53Z
dc.date.issued1998-10
dc.identifier.citationSclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria. 1998, 33 (4):354-60 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid9822926
dc.identifier.urihttp://hdl.handle.net/10541/91892
dc.description.abstractAIMS: To study the clinical and histopathological features of sclerosing epithelioid fibrosarcoma, and to define diagnostic criteria for this uncommon soft-tissue tumour. METHODS AND RESULTS: Standard histological, immunohistochemical and ultrastructural techniques were applied to five tumours from head and neck, chest wall and groin. Tumours consisted of groups of monomorphic rounded/epithelioid cells surrounded by a prominent collagenous stroma. Tumour cells showed positive vimentin staining but were negative for other markers. They contained prominent rough endoplasmic reticulum and a large Golgi apparatus which in one case was producing collagen secretion granules, an ultrastructural marker for collagen production. Three patients had medium to long-term survival (3-7 years). Of these, one was disease-free for 3 years, and two experienced multiple recurrences: one of the latter died of metastatic disease. CONCLUSION: Criteria for diagnosing this uncommon tumour include: small to medium cell size, clear or pale cytoplasm, cellular arrangement in cords and strands, dense collagenous stroma; vimentin staining; rough endoplasmic reticulum and a Golgi apparatus producing, in well preserved examples, collagen secretion granules. The paper emphasizes the value of electron microscopy, supporting an appropriate histological picture and immunophenotype, in identifying these relatively low-grade sarcomas.
dc.language.isoenen
dc.subjectSoft Tissue Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshEpithelioid Cells
dc.subject.meshFemale
dc.subject.meshFibrosarcoma
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMicroscopy, Electron
dc.subject.meshMiddle Aged
dc.subject.meshReticulin
dc.subject.meshSclerosis
dc.subject.meshSoft Tissue Neoplasms
dc.titleSclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractAIMS: To study the clinical and histopathological features of sclerosing epithelioid fibrosarcoma, and to define diagnostic criteria for this uncommon soft-tissue tumour. METHODS AND RESULTS: Standard histological, immunohistochemical and ultrastructural techniques were applied to five tumours from head and neck, chest wall and groin. Tumours consisted of groups of monomorphic rounded/epithelioid cells surrounded by a prominent collagenous stroma. Tumour cells showed positive vimentin staining but were negative for other markers. They contained prominent rough endoplasmic reticulum and a large Golgi apparatus which in one case was producing collagen secretion granules, an ultrastructural marker for collagen production. Three patients had medium to long-term survival (3-7 years). Of these, one was disease-free for 3 years, and two experienced multiple recurrences: one of the latter died of metastatic disease. CONCLUSION: Criteria for diagnosing this uncommon tumour include: small to medium cell size, clear or pale cytoplasm, cellular arrangement in cords and strands, dense collagenous stroma; vimentin staining; rough endoplasmic reticulum and a Golgi apparatus producing, in well preserved examples, collagen secretion granules. The paper emphasizes the value of electron microscopy, supporting an appropriate histological picture and immunophenotype, in identifying these relatively low-grade sarcomas.


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