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    Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer.

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    Authors
    Li, Chenggang
    Wang, Ji Min
    Wilson, Philip B
    Kumar, Patricia
    Levine, Edward
    Hunter, Robin D
    Kumar, Shant
    Affiliation
    Department of Pathology, Medical School, University of Manchester, UK.
    Issue Date
    1998-10-23
    
    Metadata
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    Abstract
    Transforming growth factor-betas (TGFbetas) play a prominent role in tumour growth and metastasis by enhancing angiogenesis and suppressing immune surveillance. Despite the increased interest in the effect of TGFbetas on tumour progression, little is known about the importance of TGFbeta3 and its receptor CD105 in breast cancer. In the present study, we measured the plasma levels of TGFbeta3, CD105-TGFbeta3 complexes and TGFbeta1 in 80 patients with untreated early-stage breast cancer using an enhanced chemiluminescence ELISA method. Of the 80 patients, 14 were histologically confirmed as having axillary lymph node metastases, while the remainder had no evidence of lymph node involvement. The results showed that levels of both TGFbeta3 and CD105-TGFbeta3 complex were significantly elevated in patients with positive lymph nodes compared to those without node metastasis. Furthermore, the levels of both TGFbeta3 and CD105-TGFbeta3 complex correlated with lymph node status. The only patient who died of the disease had very high plasma levels of TGFbeta3 and CD105-TGFbeta3 complex and positive lymph nodes; this patient developed lung metastases within 2 years of diagnosis. No significant correlation was seen between either TGFbeta3 or CD105-TGFbeta3 complex levels and tumour stage, size or histological grade. Plasma TGFbeta1 levels were not correlated with node metastasis, tumour stage, grade or size. Our data suggest that plasma levels of TGFbeta3 and CD105-TGFbeta3 complex may be of prognostic value in the early detection of metastasis of breast cancer.
    Citation
    Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer. 1998, 79 (5):455-9 Int. J. Cancer
    Journal
    International Journal of Cancer.
    URI
    http://hdl.handle.net/10541/91888
    DOI
    10.1002/(SICI)1097-0215(19981023)79:5<449::AID-IJC1>3.0.CO;2-0
    PubMed ID
    9761112
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/(SICI)1097-0215(19981023)79:5<449::AID-IJC1>3.0.CO;2-0
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