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dc.contributor.authorLissett, Catherine A
dc.contributor.authorToogood, Andy
dc.contributor.authorDidi, Mohammed
dc.contributor.authorShalet, Stephen M
dc.date.accessioned2010-02-11T16:33:02Z
dc.date.available2010-02-11T16:33:02Z
dc.date.issued1998
dc.identifier.citationGrowth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility. 1998, 50 (4):232-6 Horm. Res.en
dc.identifier.issn0301-0163
dc.identifier.pmid9838246
dc.identifier.doi10.1159/000023280
dc.identifier.urihttp://hdl.handle.net/10541/91886
dc.description.abstractWe present the case of an adult patient with growth hormone (GH) insufficiency and hereditary motor and sensory neuropathy type 1. Stopping GH replacement at the attainment of final height was associated with a marked reduction in power and mobility, resulting in the patient becoming wheelchair bound. GH replacement was assessed in a double-blind placebo-controlled trial. During the GH replacement arm of the trial, the patient's mobility and independence returned to previous levels. We suggest that the indications for GH replacement in adults should take account of other medical problems, in particular neuromuscular disorders, as well as the degree of GH deficiency.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshCharcot-Marie-Tooth Disease
dc.subject.meshDouble-Blind Method
dc.subject.meshHuman Growth Hormone
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMuscle Weakness
dc.subject.meshMuscle, Skeletal
dc.titleGrowth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Withington, Manchester, UK.en
dc.identifier.journalHormone Researchen
html.description.abstractWe present the case of an adult patient with growth hormone (GH) insufficiency and hereditary motor and sensory neuropathy type 1. Stopping GH replacement at the attainment of final height was associated with a marked reduction in power and mobility, resulting in the patient becoming wheelchair bound. GH replacement was assessed in a double-blind placebo-controlled trial. During the GH replacement arm of the trial, the patient's mobility and independence returned to previous levels. We suggest that the indications for GH replacement in adults should take account of other medical problems, in particular neuromuscular disorders, as well as the degree of GH deficiency.


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