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    Growth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility.

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    Authors
    Lissett, Catherine A
    Toogood, Andy
    Didi, Mohammed
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital, Withington, Manchester, UK.
    Issue Date
    1998
    
    Metadata
    Show full item record
    Abstract
    We present the case of an adult patient with growth hormone (GH) insufficiency and hereditary motor and sensory neuropathy type 1. Stopping GH replacement at the attainment of final height was associated with a marked reduction in power and mobility, resulting in the patient becoming wheelchair bound. GH replacement was assessed in a double-blind placebo-controlled trial. During the GH replacement arm of the trial, the patient's mobility and independence returned to previous levels. We suggest that the indications for GH replacement in adults should take account of other medical problems, in particular neuromuscular disorders, as well as the degree of GH deficiency.
    Citation
    Growth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility. 1998, 50 (4):232-6 Horm. Res.
    Journal
    Hormone Research
    URI
    http://hdl.handle.net/10541/91886
    DOI
    10.1159/000023280
    PubMed ID
    9838246
    Type
    Article
    Language
    en
    ISSN
    0301-0163
    ae974a485f413a2113503eed53cd6c53
    10.1159/000023280
    Scopus Count
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