Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody.
AffiliationDepartment of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.
MetadataShow full item record
AbstractInhibin is a peptide hormone produced by ovarian granulosa cells and testicular Sertoli cells. Ovarian granulosa cell and other sex cord-stromal tumors usually exhibit positive immunohistochemical staining with antiinhibin antibodies, and this may be valuable in differentiating these neoplasms from histologic mimics. In the present study, we investigated the immunohistochemical staining of testicular sex cord-stromal tumors using antiinhibin. Immunostaining with CAM5.2, vimentin, S-100 protein, desmin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) also was performed because few studies have investigated in detail the immunophenotype of testicular sex cord-stromal tumors. Fifteen of 16 Leydig cell tumors exhibited strong positive staining with antiinhibin. A proportion of Leydig cell tumors also stained positively with CAM5.2 (7 of 16), vimentin (14 of 16), S-100 protein (10 of 16), desmin (2 of 16) and epithelial membrane antigen (4 of 16). Four of six testicular sex cord-stromal tumors with varying degrees of Sertoli or granulosa cell differentiation were positive with antiinhibin, as were two of three sex cord-stromal tumors that were unclassified. Some of these tumors were positive with CAM 5.2, vimentin, S-100 protein, desmin, and epithelial membrane antigen. All tumors were negative with carcinoembryonic antigen and placental alkaline phosphatase. The immunohistochemical findings show that, analogous to their ovarian counterparts, most testicular sex cord-stromal tumors are immunoreactive with antiinhibin. Immunohistochemistry using this antibody as part of a panel may be valuable in confirming a diagnosis of testicular sex cord-stromal tumor and in differentiating these neoplasms from others that may mimic them.
CitationImmunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. 1998, 22 (5):615-9 Am. J. Surg. Pathol.
JournalAmerican Journal of Surgical Pathology
- Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary.
- Authors: Rishi M, Howard LN, Bratthauer GL, Tavassoli FA
- Issue date: 1997 May
- Testicular Sertoli cell tumor with a heterologous sarcomatous component: immunohistochemical assessment of Sertoli cell differentiation.
- Authors: Gilcrease MZ, Delgado R, Albores-Saavedra J
- Issue date: 1998 Oct
- Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis.
- Authors: Tanaka Y, Carney JA, Ijiri R, Kato K, Miyake T, Nakatani Y, Misugi K
- Issue date: 2002 Mar
- Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases.
- Authors: Movahedi-Lankarani S, Kurman RJ
- Issue date: 2002 Nov
- The diagnostic utility of inhibin staining in ovarian neoplasms.
- Authors: Pelkey TJ, Frierson HF Jr, Mills SE, Stoler MH
- Issue date: 1998 Apr