Authors
Thatcher, NickLee, Siow Ming
Woll, Penella J
Middleton, Mark R
Anderson, Heather
Burt, Paul A
Stout, Ronald
Affiliation
CRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1998-04
Metadata
Show full item recordAbstract
Evidence from preclinical models and from clinical trials describing the importance of dose intensity in securing a better treatment outcome is reviewed. Recent randomized trials have shown statistically significant survival benefits with higher-dose, accelerated chemotherapy regimens with and without granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. The novel use of peripheral blood progenitor cells contained in whole blood autotransfusions, which allow a marked increase in dose intensity of an ifosfamide/carboplatin/etoposide regimen, could provide a much easier method of delivering dose-intensive chemotherapy than previously available.Citation
Dose intensity in small cell lung cancer. 1998, 25 (2 Suppl 4):12-8; discussion 45-8 Semin. Oncol.Journal
Seminars in OncologyPubMed ID
9578057Type
ArticleLanguage
enISSN
0093-7754Collections
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