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dc.contributor.authorTaylor, G Malcolm
dc.contributor.authorDearden, Simon
dc.contributor.authorPayne, N
dc.contributor.authorAyres, Michelle
dc.contributor.authorGokhale, D A
dc.contributor.authorBirch, Jillian M
dc.contributor.authorBlair, Val
dc.contributor.authorStevens, Richard F
dc.contributor.authorWill, Andrew M
dc.contributor.authorEden, Tim O B
dc.date.accessioned2010-02-09T16:52:28Z
dc.date.available2010-02-09T16:52:28Z
dc.date.issued1998-09
dc.identifier.citationEvidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. 1998, 78 (5):561-5 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid9744491
dc.identifier.urihttp://hdl.handle.net/10541/91666
dc.description.abstractComparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAlleles
dc.subject.meshAntigen Presentation
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCommunicable Diseases
dc.subject.meshDNA
dc.subject.meshDisease Susceptibility
dc.subject.meshFemale
dc.subject.meshGene Frequency
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshHLA-DQ Antigens
dc.subject.meshHaplotypes
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshPolymorphism, Single-Stranded Conformational
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.subject.meshSex Factors
dc.titleEvidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.en
dc.typeArticleen
dc.contributor.departmentImmunogenetics Laboratory, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractComparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.


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